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The medical applications of Cordyceps are centered primarily on the key functions of different organs, including but not limited to lung, kidney, liver and heart. Cordyceps is also recommended as an aid to treatment of cancer, diabetes and organ transplant. Identified benignant elements such as adenosine, cordycepin, cordycepic acid, the polysaccharides and vitamins and trace elements, are believed to be partially the cause of the well-known effects.
While scientists are still in search of more key components of the fungus, numerous clinical trials have proceeded to scientifically prove that Cordyceps works well in treating and healing a myriad of medical problems. Select a topic below to read more clinical study details.
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Kidney
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Lung
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Heart
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Liver
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Diabetes
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Anti-aging
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High Cholesterol
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Cancer
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Reduce Drug Toxicity
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Kidney
Modern science has confirmed that kidney health is indeed the most important of the body's health. Kidneys failure is oftentimes the source of the problems occurring to other organs and systems, leading to various diseases and ailment. Fatigue, impotence, joint and back pain, even ringing in the ears are all symptoms of degenerative kidney health. In 1998, Dr Zhou and his team discovered that much of Cordyceps kidney enhancing potential comes from its ability to increase 17-hydroxy-corticosteroid and 17-ketosteriod levels. Many other traditional uses for the fungus can be traced back to proper kidney health.
Chronic renal failure is a serious disease affecting the elderly. In a 1992 study of 51 patients with chronic renal failure, Dr. Guan and his colleagues found that the group of patients receiving 3-5 grams per day of Cordyceps Sinensis had shown significantly improved kidney function and overall immune function, as compared to the placebo group.
Patients with kidney problems often suffer from hypertension, proteinuria and anemia. In a study with such patients it was found that after one month on Cordyceps, a 15% reduction in blood pressure was observed. Urinary protein was also significantly reduced. Additionally, increase in superoxide dismutase was documented. The study further suggests an increase in the oxygen free radical scavenging capacity, resulting in reduced oxidative cellular damage.
In another clinical study, 57 patients with gentamicin-induced kidney damage were either treated with 4.5 grams of Cordyceps per day or by other, more conventional methods. After six days, the group that received Cordyceps had recovered 89% of their normal kidney function; while the control group had recovered only 45% of normal kidney function. The time-to-recovery was also significantly shorter in the Cordyceps group when compared to the control group
Lung
In China, Cordyceps has been viewed as a promoter of respiratory health for more than a thousand years. Cordyceps is known to enhance oxygen utilization and cellular oxygen uptake. This benefits the entire body with more energy and vitality.
In environments with low oxygen levels, mice treated with Cordyceps were able to survive up to three times longer than those left untreated, evidencing more efficient oxygen utilization. This is confirmed by Cordyceps' long history of use in preventing and treating altitude sickness.
Cordyceps has been used effectively to treat Bronchitis, Asthma, and Chronic Obstructive Pulmonary Disease (COPD). Cordyceps Sinensis has been shown to inhibit tracheal contractions, especially important for asthma patients in that it allows for increased airflow to the lungs. In addition, its anti-inflammatory properties bring further relief to asthma patients, whose airways become obstructed, due to an allergic reaction resulting in swelling of the bronchial pathways. In a clinical trial involving 50 asthma patients, efficacy against symptoms among the group treated with Cordyceps was 81.3%, within an average of five days; while among those treated with conventional antihistamines the rate was only 61.1%, and took an average of nine days for symptoms to subside.
There has been very extensive trails in humans, using Cordyceps to treat all manner of respiratory illnesses, including asthma, COPD, and bronchitis, either alone or as an adjunct to standard antibiotic therapy. It has proven useful for all of these conditions. What has been observed for centuries by thousands of TCM practitioners, that Cordyceps improves respiratory function, is now a well-proven and well-accepted scientific fact.
Heart
One of the most important benefits of Cordyceps is its ability to stabilize the heart beat and correct heart arrhythmias. This fungus is on top of the list of choices for this serious condition in China today. Exact mechanism is only partly understood. One study pointed to the presence of adenosine. Cordyceps contains a significant amount of adenosine, deoxyadenosine and related adenosine type nucleotides. Those compounds have great impact on coronary and cerebral circulation.
Cordyceps doesn't interfere with any other arrhythmia medication. With low toxicity, Cordyceps has become an excellent choice for this condition.
Cordyceps has been used traditionally for many other heart diseases. It benefits the vascular system by improving circulation, regulating blood pressure, and strengthening the heart muscle.
In a long-term study of patients with chronic heart failure, continuous use of Cordyceps in combination with conventional treatments promoted an increase in the overall quality of life. This included general physical condition, mental health, and cardiac function, compared to the control group.
Liver
Protecting liver and kidneys. Cordyceps improves blood flow to these organs (as well as to the others), which results in their better activity and ability to fight the diseases, including Hepatitis and chronic kidney disease.
Large amount of research has been done on Cordyceps' benefits on liver function. Nearly all such studies confirmed that Cordyceps enhances liver function. Cordyceps is commonly used as an adjunct in the treatment of Hepatitis B and C.
In one study, Cordyceps was used with lamivudine for the treatment of Hepatitis B. The group receiving Cordyceps had a much better outcome in a shorter period of time than the control group who received only the lamivudine.
In another study of 22 patients with post hepatic cirrhosis, all patients showed dramatic improvement in liver function tests, after 3 months of 6-9 grams of Cordyceps daily.
Diabetes
Another area where there has been a lot of research done is in the effect of Cordyceps on the blood glucose metabolism system. Diabetes is a serious problem, especially in countries with a Western diet.
Cordyceps has been tested in a number of animal and human studies for its potential as a blood sugar regulation agent. The results are very promising. In one clinical study, 95% of the patients treated with 3 grams Cordyceps daily saw improvement in their blood sugar measurement, while the control group showed only 54% improvement with traditional treatment.
In one animal trial by Kiho in 2000, Cordyceps was found to lower blood sugar levels in genetically diabetic animals. Another animal trial by Dr. Zhao and his team in 2002 showed that Cordyceps improves blood glucose metabolism and increases insulin sensitivity in normal animals. In another 2002 animal study by Hao and Chen concluded that Cordyceps positively affect blood sugar metabolism in animals with chemically induced diabetes. The common thread throughout all of these trials is the increase in insulin sensitivity and the increase in the livers' output of the glucose regulating enzymes. In short, it appears that regardless of the cause or classification, Cordyceps is a great treatment for diabetes, either as a single agent or in conjunction with other drugs.
In one clinical study, non-diabetic patients were treated with 3 grams Cordyceps daily. Researchers found that the normal blood sugar change curve was significantly flattened in the Cordyceps group. In other words, the blood sugar did not go as high after eating, and it did not drop down as low between meals. This study again proved that Cordyceps has the ability to regulate blood sugar level.
Anti-aging
One instantly noticeable benefit of Cordyceps is that it provides anti-aging and fatigue reducing effects. The fungus works as an antioxidant and increases cellular formation, especially in the seniors. It also promotes more restful sleep, soothes the nervous system, and reduces anxiety. Cordyceps is commonly used as an overall rejuvenator for patients recovering from serious illness.
Aging is the direct result of body's declining ability to obtain and use oxygen. In a recent study, Dr. Guo confirmed that Cordyceps usage increase the cellular ATP level. ATP (adenosine triphosphate) is the compound that consumes oxygen and releases energy in the cell. An increase in cellular ATP means a real increase in actual energy, energy that is available for use. This contrasts to the perceived increase in energy such as that which occurs from the use of CNS stimulants such as caffeine, ephedrine and the amphetamines. Another 2004 study by Dr. Zhu, showed that Cordyceps enhances oxygen utilization.
High Cholesterol
Hypercholesterolemia is a clear indicator of dysfunction of the metabolism and an indicator of increased cardiovascular risk. The liver is the main source of both cholesterol production and elimination; therefore it stands to reason that any disorders of the liver could affect the blood levels of cholesterol and triglyceride. It is also well known that diabetes can and usually does lead to hyperlipidemia.
Cordyceps is well proven through many formal trials and clinical observations to act in a positive way with regards to maintaining healthy cholesterol and triglyceride levels. In both human and animal studies, administration of Cordyceps has been associated with cholesterol and triglyceride reduction and an increase in ratio of HDL to LDL cholesterol.
Cancer
One of the most promising benefits of Cordyceps is its anti-cancer effect. More and more doctors worldwide recommend Cordyceps as an alternative, or addition to chemotherapy, radiation and other traditional cancer treatments. It has been used successfully to stop the growth of cancer cells, and to dissolve cancerous tumors. Clinical studies have proven that Cordyceps has the ability to enhance and strengthen the immune system. It helps the body to more efficiently manage its immune resources while undergoing the stresses of the attack by cancer.
This secondary effect is extremely important for patients going through chemotherapy or radiation treatment, in that it keeps body strong against the side effects of those treatments. It is no longer a secret that many more patients die of opportunistic infections during chemotherapy than ever die of the cancer itself. The use of Cordyceps will minimize the risk of complication.
Many clinical studies have shown positive results. In one study, fifty patients with lung cancer were given 6 grams of Cordyceps daily in conjunction with chemotherapy. Tumors were reduced in size in 46% of the patients. A trial involving cancer patients with several different types of tumors found that Cordyceps taken over a two month period at 6 grams a day, improved subjective symptoms in majority of the patients. White blood cell counts were kept high while tumor size was significantly reduced in approximately half of the patients.
Reduce Drug Toxicity
Many popular drugs have quite considerable toxicity, and it is hoped that the incorporation of Cordyceps into the treatment regimen of those patients undergoing such therapy might result in a reduction of some of these more toxic synthetic drugs, while sacrificing none of the efficacy.
Organ transplant is a good example of how Cordyceps can be used in conjunction with drugs. Cyclosporin is a well-known drug for organ transplant. The problem is its toxicity. Many patients suffer from serious kidney damage after using Cyclosporin. In a 1995 clinical study, 69 kidney transplant patients were given either Cyclosporin alone, or in conjunction with Cordyceps Sinensis at 3 grams a day. After 15 days it was clearly evident that the group receiving Cordyceps Sinensis in addition to the Cyclosporin had a much lower incidence of kidney failure than the group receiving only the Cyclosporin.
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